![]() Furthermore, the oxygen carrying capacity was maintained in poisoned mice treated with metHb-albumin clusters and was low in those treated with NaNO 2. In mice subjected to cyanide poisoning, metHb-albumin clusters reduced mortality and alleviated metabolic acidosis, while maintaining the activity of cytochrome c oxidase in organs their efficacy was better than that of NaNO 2. ![]() In vitro cell experiments showed that metHb-albumin clusters prevented the cyanide-induced inhibition of cytochrome c oxidase activity, resulting in a strong cytoprotective effect. Spectral analyses proved that the metHb-albumin clusters possessed cyanide-binding properties similar to those of naked metHb. The metHb-albumin cluster is made by a metHb core wrapped by covalently bound human serum albumin. Herein, we present a promising antidote: methemoglobin (metHb)-albumin clusters. However, its use has serious drawbacks in terms of efficacy and safety. ![]() Sodium nitrite (NaNO 2) is a universal antidote for patients with cyanide poisoning.
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